Identification of multipotent progenitors has been difficult due to their rarity in adults. Here, we report a novel type of neuroepithelial myogenic progenitor that can be isolated from adult murine skeletal muscle. In culture, these progenitors generated radial glia-like cells that initiated mosaic myotubes, and subsequently developed into embryonic/fetal-like myoblasts capable of robust myofiber formation. These cells could also differentiate into neuronal lineage. By contrast, progenitors from bone marrow produced progenies more uniformly of an adult myoblast lineage. When grafted into dystrophic muscles of mdx mice, the muscle- and marrow-derived cells restored dystrophin expression; however, fetal-like myogenesis towards a defective adult fate was demonstrated in the muscle-derived cells. This impaired regenerative capacity resembled Duchenne muscular dystrophy patients, suggesting a potential connection between the neuroepithelial myogenic progenitor and the etiology of this myopathy. The distinct fates of the two types of progenitors imply their different roles in muscle regeneration and pathogenesis.
| Published in | Cell Biology (Volume 3, Issue 4) |
| DOI | 10.11648/j.cb.20150304.12 |
| Page(s) | 58-73 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Neuroepithelial Myogenic Progenitors, Bone Marrow Myogenic Cells, Neural Differentiation, Myogenesis, Cell Transplantation, Muscular Dystrophy
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APA Style
Zhuqing Qu-Petersen, Jesper L. Andersen, Shi Zhou. (2015). Distinct Embryonic and Adult Fates of Multipotent Myogenic Progenitors Isolated from Skeletal Muscle and Bone Marrow. Cell Biology, 3(4), 58-73. https://doi.org/10.11648/j.cb.20150304.12
ACS Style
Zhuqing Qu-Petersen; Jesper L. Andersen; Shi Zhou. Distinct Embryonic and Adult Fates of Multipotent Myogenic Progenitors Isolated from Skeletal Muscle and Bone Marrow. Cell Biol. 2015, 3(4), 58-73. doi: 10.11648/j.cb.20150304.12
AMA Style
Zhuqing Qu-Petersen, Jesper L. Andersen, Shi Zhou. Distinct Embryonic and Adult Fates of Multipotent Myogenic Progenitors Isolated from Skeletal Muscle and Bone Marrow. Cell Biol. 2015;3(4):58-73. doi: 10.11648/j.cb.20150304.12
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Download@article{10.11648/j.cb.20150304.12,
author = {Zhuqing Qu-Petersen and Jesper L. Andersen and Shi Zhou},
title = {Distinct Embryonic and Adult Fates of Multipotent Myogenic Progenitors Isolated from Skeletal Muscle and Bone Marrow},
journal = {Cell Biology},
volume = {3},
number = {4},
pages = {58-73},
doi = {10.11648/j.cb.20150304.12},
url = {https://doi.org/10.11648/j.cb.20150304.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150304.12},
abstract = {Identification of multipotent progenitors has been difficult due to their rarity in adults. Here, we report a novel type of neuroepithelial myogenic progenitor that can be isolated from adult murine skeletal muscle. In culture, these progenitors generated radial glia-like cells that initiated mosaic myotubes, and subsequently developed into embryonic/fetal-like myoblasts capable of robust myofiber formation. These cells could also differentiate into neuronal lineage. By contrast, progenitors from bone marrow produced progenies more uniformly of an adult myoblast lineage. When grafted into dystrophic muscles of mdx mice, the muscle- and marrow-derived cells restored dystrophin expression; however, fetal-like myogenesis towards a defective adult fate was demonstrated in the muscle-derived cells. This impaired regenerative capacity resembled Duchenne muscular dystrophy patients, suggesting a potential connection between the neuroepithelial myogenic progenitor and the etiology of this myopathy. The distinct fates of the two types of progenitors imply their different roles in muscle regeneration and pathogenesis.},
year = {2015}
}
TY - JOUR T1 - Distinct Embryonic and Adult Fates of Multipotent Myogenic Progenitors Isolated from Skeletal Muscle and Bone Marrow AU - Zhuqing Qu-Petersen AU - Jesper L. Andersen AU - Shi Zhou Y1 - 2015/12/30 PY - 2015 N1 - https://doi.org/10.11648/j.cb.20150304.12 DO - 10.11648/j.cb.20150304.12 T2 - Cell Biology JF - Cell Biology JO - Cell Biology SP - 58 EP - 73 PB - Science Publishing Group SN - 2330-0183 UR - https://doi.org/10.11648/j.cb.20150304.12 AB - Identification of multipotent progenitors has been difficult due to their rarity in adults. Here, we report a novel type of neuroepithelial myogenic progenitor that can be isolated from adult murine skeletal muscle. In culture, these progenitors generated radial glia-like cells that initiated mosaic myotubes, and subsequently developed into embryonic/fetal-like myoblasts capable of robust myofiber formation. These cells could also differentiate into neuronal lineage. By contrast, progenitors from bone marrow produced progenies more uniformly of an adult myoblast lineage. When grafted into dystrophic muscles of mdx mice, the muscle- and marrow-derived cells restored dystrophin expression; however, fetal-like myogenesis towards a defective adult fate was demonstrated in the muscle-derived cells. This impaired regenerative capacity resembled Duchenne muscular dystrophy patients, suggesting a potential connection between the neuroepithelial myogenic progenitor and the etiology of this myopathy. The distinct fates of the two types of progenitors imply their different roles in muscle regeneration and pathogenesis. VL - 3 IS - 4 ER -
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